Review



resource source identifier recombinant human il 15 protein  (R&D Systems)


Bioz Verified Symbol R&D Systems is a verified supplier
Bioz Manufacturer Symbol R&D Systems manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 95
      Buy from Supplier

    Structured Review

    R&D Systems resource source identifier recombinant human il 15 protein
    Resource Source Identifier Recombinant Human Il 15 Protein, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 198 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/resource+source+identifier+recombinant+human+il+15+protein/Recombinant+Human+IL-15+Protein/pm42013863-236-2-10
    Average 95 stars, based on 198 article reviews
    resource source identifier recombinant human il 15 protein - by Bioz Stars, 2026-09
    95/100 stars

    Images

    Related Articles

    Recombinant:

    Article Title: Organ injury in systemic autoimmunity is mediated by stem-like CD8 + T cells arising from tissue-draining lymph nodes.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PE anti-mouse IL-21R Antibody Biolegend Cat#131906; RRID:AB_1279430 BD PharmingenTM Purified NA/LE Hamster Anti-Mouse CD3e BD Biosciences Cat#553057; RRID:AB_394590 BD PharmingenTM Purified NA/LE Mouse Anti-Mouse CD28 BD Biosciences Cat#566883; RRID:AB_2869934 Ultra-LEAFTM Purified anti-mouse CD8a Antibody Biolegend Cat#100764; RRID:AB_2810324 Ultra-LEAFTM Purified Rat IgG2a, κ Isotype Ctrl Antibody Biolegend Cat#400566; RRID:AB_11148951 TotalSeqTM-C0301 anti-mouse Hashtag 1 Antibody Biolegend Cat#155861; RRID:AB_2800693 TotalSeqTM-C0302 anti-mouse Hashtag 2 Antibody Biolegend Cat#155863; RRID:AB_2800694 TotalSeqTM-C0303 anti-mouse Hashtag 3 Antibody Biolegend Cat#155865; RRID:AB_2800695 InVivoMAb rat IgG2a isotype control, antitrinitrophenol BioXCell Cat#BE0089; RRID:AB_1107769 InVivoMAb anti-mouse CD122 (IL-2Rβ) BioXCell Cat#BE0272; RRID:AB_2687795 InVivoMAb anti-mouse IL-21R BioXCell Cat#BE0258; RRID:AB_2687737 InVivoMAb anti-mouse PD-1 (CD279) BioXCell Cat#BE0273; RRID:AB_2687796 CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscienceTM Invitrogen Cat#16-0037-85; RRID:AB_468855 CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscienceTM Invitrogen Cat#16-0289-85; RRID:AB_468927 anti-Nephrin guinea pig polyclonal, serum PROGEN Cat#GP-N2; RRID:AB_2904121 Complement C3 Polyclonal Antibody Invitrogen Cat#PA5-21349; RRID:AB_11153785 APC Goat anti-mouse IgG (minimal x-reactivity) Antibody Biolegend Cat#405308; RRID:AB_315011 Goat Anti-Guinea pig IgG H&L (Alexa Fluor® 488) Abcam Cat#ab150185; RRID:AB_2736871 Goat Anti-Mouse IgG, Human ads-AP SouthernBiotech Cat#1030-04; RRID:AB_2794293 Biological samples Lupus patient PBMCs Yale University N/A Chemicals, peptides, and recombinant proteins LIVE/DEADTM Fixable Aqua Dead Cell Stain Kit Invitrogen Cat#L34966 Recombinant Mouse IFN-gamma Protein with carrier R&D Systems Cat#485-MI-100 Recombinant Mouse TNF-alpha (aa 80-235) Protein with carrier R&D Systems Cat#410-MT-025 Recombinant Mouse IL-10 Protein with carrier R&D Systems Cat#417-ML-025 Recombinant Mouse IL-12 Protein with carrier R&D Systems Cat#419-ML-010 Recombinant Mouse IL-15 Protein with carrier R&D Systems Ca#447-ML-010 Recombinant Mouse IL-18/IL-1F4 Protein with carrier R&D Systems Cat#9139-IL-050 Recombinant Mouse IL-21 Protein with carrier R&D Systems Cat#594-ML-025 Universal Type I IFN Protein R&D Systems Cat#11200-1 Human IL-2 Recombinant Protein PeproTech Cat#200-02 (Continued on next page) ll OPEN ACCESSArticle Immunity 59, 1–21.e1–e15, June 9, 2026 e2 .. REAGENT or RESOURCE SOURCE IDENTIFIER Recombinant Human IL-15 Protein, CF R&D Systems Cat#BT-015-010 Recombinant Human IL-21 Protein with carrier R&D Systems Cat#8879-IL-010 FTY720 MilliporeSigma Cat344597; CAS:162359-56-0 Deoxyribonucleic acid from calf thymus MilliporeSigma Cat#D4522; CAS:91080-16-9 Reacti-Bind TM DNA Coating Solution Thermo Fisher Cat#17250 DAPI Nucleic Acid Stains Invitrogen Cat#D1306 ProLongTM Gold Antifade Mountant Invitrogen Cat#P36930 Collagenase from Clostridium histolyticum MilliporeSigma Cat#C9263; CAS: 9001-12-1 Renal Epithelial Cell Basal Medium ATCC Cat#PCS-400-030 Critical commercial assays Chromium Next GEM Single Cell Multiome ATAC + Gene Expression 10x Genomics Cat#CG000365 Chromium GEM-X Single Cell 5’ Kit 10x Genomics Cat#CG000733 EasySep Mouse CD4+ TCell Isolation Kit STEMCELL Technologies Cat#19852 EasySep Mouse CD8+ TCell Isolation Kit STEMCELL Technologies Cat#19853A EasySepTM Human CD8+ T Cell Isolation Kit STEMCELL Technologies Cat#17953 eBioscienceTM Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent Invitrogen Cat#00-5521-00 PierceTM Bradford Protein Assay Kit Thermo Scientific Cat#23200 QuantiChromTM Creatinine Assay Kit BioAssay Systems Cat#DICT-500 BD PharmingenTM PE Annexin V Apoptosis Detection Kit I BD Biosciences Cat#559763; RRID:AB_2869265 Deposited data Mouse single cell sequencing data This study Gene Expression Omnibus (GEO) accession number: GSE318514 Human single cell sequencing data Accelerating Medicines Partnership Phase II RA/SLE AMP2 Lupus Kidney Single Cell Mouse strains MRL/MpJ-Faslpr/J The Jackson Laboratory 000485; RRID:IMSR_JAX:000485 NZBWF1/J The Jackson Laboratory 100008; RRID:IMSR_JAX:100008 B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ The Jackson Laboratory 021569; RRID:IMSR_JAX:021569 B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J The Jackson Laboratory 018974; RRID:IMSR_JAX:018974 C57BL/6J The Jackson Laboratory 000664; RRID:IMSR_JAX:000664 MRL/MpJ-Faslpr/J × B6N.B6-Tg(Nr4a1EGFP/cre)820Khog This study N/A MRL/MpJ-Faslpr/J.TCRβ-/- Peng et al.53 10.1084/jem.184.3.1149 Software and algorithms FlowJo v10.8.1 TreeStar FlowJo LLC. .. RRID:SCR_008520 GraphPad Prism v9.5.1 GraphPad Software RRID:SCR_002798 ImageJ imagej.net/ij RRID:SCR_003070 CellRanger v5.0.1 10xgenomics.com/support/software/ cell-ranger RRID:SCR_023221 R version 4.2.0 r-project.org RRID:SCR_001905 chromVAR v1.18 bioconductor.org/packages/chromVAR RRID:SCR_026570 circlize v0.4.16 cran.r-project.org/web/packages/circlize RRID:SCR_002141 cisTopic v0.3.0 github.com/aertslab/cisTopic N/A clusterProfiler v4.6.2 bioconductor.org/packages/clusterProfiler RRID:SCR_016884 Clustree v0.5.0 cran.r-project.org/web/packages/ clustree/index RRID:SCR_016293 (Continued on next page) ll OPEN ACCESS Article e3 Immunity 59, 1–21.e1–e15, June 9, 2026

    Single Cell:

    Article Title: Organ injury in systemic autoimmunity is mediated by stem-like CD8 + T cells arising from tissue-draining lymph nodes.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PE anti-mouse IL-21R Antibody Biolegend Cat#131906; RRID:AB_1279430 BD PharmingenTM Purified NA/LE Hamster Anti-Mouse CD3e BD Biosciences Cat#553057; RRID:AB_394590 BD PharmingenTM Purified NA/LE Mouse Anti-Mouse CD28 BD Biosciences Cat#566883; RRID:AB_2869934 Ultra-LEAFTM Purified anti-mouse CD8a Antibody Biolegend Cat#100764; RRID:AB_2810324 Ultra-LEAFTM Purified Rat IgG2a, κ Isotype Ctrl Antibody Biolegend Cat#400566; RRID:AB_11148951 TotalSeqTM-C0301 anti-mouse Hashtag 1 Antibody Biolegend Cat#155861; RRID:AB_2800693 TotalSeqTM-C0302 anti-mouse Hashtag 2 Antibody Biolegend Cat#155863; RRID:AB_2800694 TotalSeqTM-C0303 anti-mouse Hashtag 3 Antibody Biolegend Cat#155865; RRID:AB_2800695 InVivoMAb rat IgG2a isotype control, antitrinitrophenol BioXCell Cat#BE0089; RRID:AB_1107769 InVivoMAb anti-mouse CD122 (IL-2Rβ) BioXCell Cat#BE0272; RRID:AB_2687795 InVivoMAb anti-mouse IL-21R BioXCell Cat#BE0258; RRID:AB_2687737 InVivoMAb anti-mouse PD-1 (CD279) BioXCell Cat#BE0273; RRID:AB_2687796 CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscienceTM Invitrogen Cat#16-0037-85; RRID:AB_468855 CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscienceTM Invitrogen Cat#16-0289-85; RRID:AB_468927 anti-Nephrin guinea pig polyclonal, serum PROGEN Cat#GP-N2; RRID:AB_2904121 Complement C3 Polyclonal Antibody Invitrogen Cat#PA5-21349; RRID:AB_11153785 APC Goat anti-mouse IgG (minimal x-reactivity) Antibody Biolegend Cat#405308; RRID:AB_315011 Goat Anti-Guinea pig IgG H&L (Alexa Fluor® 488) Abcam Cat#ab150185; RRID:AB_2736871 Goat Anti-Mouse IgG, Human ads-AP SouthernBiotech Cat#1030-04; RRID:AB_2794293 Biological samples Lupus patient PBMCs Yale University N/A Chemicals, peptides, and recombinant proteins LIVE/DEADTM Fixable Aqua Dead Cell Stain Kit Invitrogen Cat#L34966 Recombinant Mouse IFN-gamma Protein with carrier R&D Systems Cat#485-MI-100 Recombinant Mouse TNF-alpha (aa 80-235) Protein with carrier R&D Systems Cat#410-MT-025 Recombinant Mouse IL-10 Protein with carrier R&D Systems Cat#417-ML-025 Recombinant Mouse IL-12 Protein with carrier R&D Systems Cat#419-ML-010 Recombinant Mouse IL-15 Protein with carrier R&D Systems Ca#447-ML-010 Recombinant Mouse IL-18/IL-1F4 Protein with carrier R&D Systems Cat#9139-IL-050 Recombinant Mouse IL-21 Protein with carrier R&D Systems Cat#594-ML-025 Universal Type I IFN Protein R&D Systems Cat#11200-1 Human IL-2 Recombinant Protein PeproTech Cat#200-02 (Continued on next page) ll OPEN ACCESSArticle Immunity 59, 1–21.e1–e15, June 9, 2026 e2 .. REAGENT or RESOURCE SOURCE IDENTIFIER Recombinant Human IL-15 Protein, CF R&D Systems Cat#BT-015-010 Recombinant Human IL-21 Protein with carrier R&D Systems Cat#8879-IL-010 FTY720 MilliporeSigma Cat344597; CAS:162359-56-0 Deoxyribonucleic acid from calf thymus MilliporeSigma Cat#D4522; CAS:91080-16-9 Reacti-Bind TM DNA Coating Solution Thermo Fisher Cat#17250 DAPI Nucleic Acid Stains Invitrogen Cat#D1306 ProLongTM Gold Antifade Mountant Invitrogen Cat#P36930 Collagenase from Clostridium histolyticum MilliporeSigma Cat#C9263; CAS: 9001-12-1 Renal Epithelial Cell Basal Medium ATCC Cat#PCS-400-030 Critical commercial assays Chromium Next GEM Single Cell Multiome ATAC + Gene Expression 10x Genomics Cat#CG000365 Chromium GEM-X Single Cell 5’ Kit 10x Genomics Cat#CG000733 EasySep Mouse CD4+ TCell Isolation Kit STEMCELL Technologies Cat#19852 EasySep Mouse CD8+ TCell Isolation Kit STEMCELL Technologies Cat#19853A EasySepTM Human CD8+ T Cell Isolation Kit STEMCELL Technologies Cat#17953 eBioscienceTM Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent Invitrogen Cat#00-5521-00 PierceTM Bradford Protein Assay Kit Thermo Scientific Cat#23200 QuantiChromTM Creatinine Assay Kit BioAssay Systems Cat#DICT-500 BD PharmingenTM PE Annexin V Apoptosis Detection Kit I BD Biosciences Cat#559763; RRID:AB_2869265 Deposited data Mouse single cell sequencing data This study Gene Expression Omnibus (GEO) accession number: GSE318514 Human single cell sequencing data Accelerating Medicines Partnership Phase II RA/SLE AMP2 Lupus Kidney Single Cell Mouse strains MRL/MpJ-Faslpr/J The Jackson Laboratory 000485; RRID:IMSR_JAX:000485 NZBWF1/J The Jackson Laboratory 100008; RRID:IMSR_JAX:100008 B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ The Jackson Laboratory 021569; RRID:IMSR_JAX:021569 B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J The Jackson Laboratory 018974; RRID:IMSR_JAX:018974 C57BL/6J The Jackson Laboratory 000664; RRID:IMSR_JAX:000664 MRL/MpJ-Faslpr/J × B6N.B6-Tg(Nr4a1EGFP/cre)820Khog This study N/A MRL/MpJ-Faslpr/J.TCRβ-/- Peng et al.53 10.1084/jem.184.3.1149 Software and algorithms FlowJo v10.8.1 TreeStar FlowJo LLC. .. RRID:SCR_008520 GraphPad Prism v9.5.1 GraphPad Software RRID:SCR_002798 ImageJ imagej.net/ij RRID:SCR_003070 CellRanger v5.0.1 10xgenomics.com/support/software/ cell-ranger RRID:SCR_023221 R version 4.2.0 r-project.org RRID:SCR_001905 chromVAR v1.18 bioconductor.org/packages/chromVAR RRID:SCR_026570 circlize v0.4.16 cran.r-project.org/web/packages/circlize RRID:SCR_002141 cisTopic v0.3.0 github.com/aertslab/cisTopic N/A clusterProfiler v4.6.2 bioconductor.org/packages/clusterProfiler RRID:SCR_016884 Clustree v0.5.0 cran.r-project.org/web/packages/ clustree/index RRID:SCR_016293 (Continued on next page) ll OPEN ACCESS Article e3 Immunity 59, 1–21.e1–e15, June 9, 2026

    Gene Expression:

    Article Title: Organ injury in systemic autoimmunity is mediated by stem-like CD8 + T cells arising from tissue-draining lymph nodes.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PE anti-mouse IL-21R Antibody Biolegend Cat#131906; RRID:AB_1279430 BD PharmingenTM Purified NA/LE Hamster Anti-Mouse CD3e BD Biosciences Cat#553057; RRID:AB_394590 BD PharmingenTM Purified NA/LE Mouse Anti-Mouse CD28 BD Biosciences Cat#566883; RRID:AB_2869934 Ultra-LEAFTM Purified anti-mouse CD8a Antibody Biolegend Cat#100764; RRID:AB_2810324 Ultra-LEAFTM Purified Rat IgG2a, κ Isotype Ctrl Antibody Biolegend Cat#400566; RRID:AB_11148951 TotalSeqTM-C0301 anti-mouse Hashtag 1 Antibody Biolegend Cat#155861; RRID:AB_2800693 TotalSeqTM-C0302 anti-mouse Hashtag 2 Antibody Biolegend Cat#155863; RRID:AB_2800694 TotalSeqTM-C0303 anti-mouse Hashtag 3 Antibody Biolegend Cat#155865; RRID:AB_2800695 InVivoMAb rat IgG2a isotype control, antitrinitrophenol BioXCell Cat#BE0089; RRID:AB_1107769 InVivoMAb anti-mouse CD122 (IL-2Rβ) BioXCell Cat#BE0272; RRID:AB_2687795 InVivoMAb anti-mouse IL-21R BioXCell Cat#BE0258; RRID:AB_2687737 InVivoMAb anti-mouse PD-1 (CD279) BioXCell Cat#BE0273; RRID:AB_2687796 CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscienceTM Invitrogen Cat#16-0037-85; RRID:AB_468855 CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscienceTM Invitrogen Cat#16-0289-85; RRID:AB_468927 anti-Nephrin guinea pig polyclonal, serum PROGEN Cat#GP-N2; RRID:AB_2904121 Complement C3 Polyclonal Antibody Invitrogen Cat#PA5-21349; RRID:AB_11153785 APC Goat anti-mouse IgG (minimal x-reactivity) Antibody Biolegend Cat#405308; RRID:AB_315011 Goat Anti-Guinea pig IgG H&L (Alexa Fluor® 488) Abcam Cat#ab150185; RRID:AB_2736871 Goat Anti-Mouse IgG, Human ads-AP SouthernBiotech Cat#1030-04; RRID:AB_2794293 Biological samples Lupus patient PBMCs Yale University N/A Chemicals, peptides, and recombinant proteins LIVE/DEADTM Fixable Aqua Dead Cell Stain Kit Invitrogen Cat#L34966 Recombinant Mouse IFN-gamma Protein with carrier R&D Systems Cat#485-MI-100 Recombinant Mouse TNF-alpha (aa 80-235) Protein with carrier R&D Systems Cat#410-MT-025 Recombinant Mouse IL-10 Protein with carrier R&D Systems Cat#417-ML-025 Recombinant Mouse IL-12 Protein with carrier R&D Systems Cat#419-ML-010 Recombinant Mouse IL-15 Protein with carrier R&D Systems Ca#447-ML-010 Recombinant Mouse IL-18/IL-1F4 Protein with carrier R&D Systems Cat#9139-IL-050 Recombinant Mouse IL-21 Protein with carrier R&D Systems Cat#594-ML-025 Universal Type I IFN Protein R&D Systems Cat#11200-1 Human IL-2 Recombinant Protein PeproTech Cat#200-02 (Continued on next page) ll OPEN ACCESSArticle Immunity 59, 1–21.e1–e15, June 9, 2026 e2 .. REAGENT or RESOURCE SOURCE IDENTIFIER Recombinant Human IL-15 Protein, CF R&D Systems Cat#BT-015-010 Recombinant Human IL-21 Protein with carrier R&D Systems Cat#8879-IL-010 FTY720 MilliporeSigma Cat344597; CAS:162359-56-0 Deoxyribonucleic acid from calf thymus MilliporeSigma Cat#D4522; CAS:91080-16-9 Reacti-Bind TM DNA Coating Solution Thermo Fisher Cat#17250 DAPI Nucleic Acid Stains Invitrogen Cat#D1306 ProLongTM Gold Antifade Mountant Invitrogen Cat#P36930 Collagenase from Clostridium histolyticum MilliporeSigma Cat#C9263; CAS: 9001-12-1 Renal Epithelial Cell Basal Medium ATCC Cat#PCS-400-030 Critical commercial assays Chromium Next GEM Single Cell Multiome ATAC + Gene Expression 10x Genomics Cat#CG000365 Chromium GEM-X Single Cell 5’ Kit 10x Genomics Cat#CG000733 EasySep Mouse CD4+ TCell Isolation Kit STEMCELL Technologies Cat#19852 EasySep Mouse CD8+ TCell Isolation Kit STEMCELL Technologies Cat#19853A EasySepTM Human CD8+ T Cell Isolation Kit STEMCELL Technologies Cat#17953 eBioscienceTM Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent Invitrogen Cat#00-5521-00 PierceTM Bradford Protein Assay Kit Thermo Scientific Cat#23200 QuantiChromTM Creatinine Assay Kit BioAssay Systems Cat#DICT-500 BD PharmingenTM PE Annexin V Apoptosis Detection Kit I BD Biosciences Cat#559763; RRID:AB_2869265 Deposited data Mouse single cell sequencing data This study Gene Expression Omnibus (GEO) accession number: GSE318514 Human single cell sequencing data Accelerating Medicines Partnership Phase II RA/SLE AMP2 Lupus Kidney Single Cell Mouse strains MRL/MpJ-Faslpr/J The Jackson Laboratory 000485; RRID:IMSR_JAX:000485 NZBWF1/J The Jackson Laboratory 100008; RRID:IMSR_JAX:100008 B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ The Jackson Laboratory 021569; RRID:IMSR_JAX:021569 B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J The Jackson Laboratory 018974; RRID:IMSR_JAX:018974 C57BL/6J The Jackson Laboratory 000664; RRID:IMSR_JAX:000664 MRL/MpJ-Faslpr/J × B6N.B6-Tg(Nr4a1EGFP/cre)820Khog This study N/A MRL/MpJ-Faslpr/J.TCRβ-/- Peng et al.53 10.1084/jem.184.3.1149 Software and algorithms FlowJo v10.8.1 TreeStar FlowJo LLC. .. RRID:SCR_008520 GraphPad Prism v9.5.1 GraphPad Software RRID:SCR_002798 ImageJ imagej.net/ij RRID:SCR_003070 CellRanger v5.0.1 10xgenomics.com/support/software/ cell-ranger RRID:SCR_023221 R version 4.2.0 r-project.org RRID:SCR_001905 chromVAR v1.18 bioconductor.org/packages/chromVAR RRID:SCR_026570 circlize v0.4.16 cran.r-project.org/web/packages/circlize RRID:SCR_002141 cisTopic v0.3.0 github.com/aertslab/cisTopic N/A clusterProfiler v4.6.2 bioconductor.org/packages/clusterProfiler RRID:SCR_016884 Clustree v0.5.0 cran.r-project.org/web/packages/ clustree/index RRID:SCR_016293 (Continued on next page) ll OPEN ACCESS Article e3 Immunity 59, 1–21.e1–e15, June 9, 2026

    Isolation:

    Article Title: Organ injury in systemic autoimmunity is mediated by stem-like CD8 + T cells arising from tissue-draining lymph nodes.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PE anti-mouse IL-21R Antibody Biolegend Cat#131906; RRID:AB_1279430 BD PharmingenTM Purified NA/LE Hamster Anti-Mouse CD3e BD Biosciences Cat#553057; RRID:AB_394590 BD PharmingenTM Purified NA/LE Mouse Anti-Mouse CD28 BD Biosciences Cat#566883; RRID:AB_2869934 Ultra-LEAFTM Purified anti-mouse CD8a Antibody Biolegend Cat#100764; RRID:AB_2810324 Ultra-LEAFTM Purified Rat IgG2a, κ Isotype Ctrl Antibody Biolegend Cat#400566; RRID:AB_11148951 TotalSeqTM-C0301 anti-mouse Hashtag 1 Antibody Biolegend Cat#155861; RRID:AB_2800693 TotalSeqTM-C0302 anti-mouse Hashtag 2 Antibody Biolegend Cat#155863; RRID:AB_2800694 TotalSeqTM-C0303 anti-mouse Hashtag 3 Antibody Biolegend Cat#155865; RRID:AB_2800695 InVivoMAb rat IgG2a isotype control, antitrinitrophenol BioXCell Cat#BE0089; RRID:AB_1107769 InVivoMAb anti-mouse CD122 (IL-2Rβ) BioXCell Cat#BE0272; RRID:AB_2687795 InVivoMAb anti-mouse IL-21R BioXCell Cat#BE0258; RRID:AB_2687737 InVivoMAb anti-mouse PD-1 (CD279) BioXCell Cat#BE0273; RRID:AB_2687796 CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscienceTM Invitrogen Cat#16-0037-85; RRID:AB_468855 CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscienceTM Invitrogen Cat#16-0289-85; RRID:AB_468927 anti-Nephrin guinea pig polyclonal, serum PROGEN Cat#GP-N2; RRID:AB_2904121 Complement C3 Polyclonal Antibody Invitrogen Cat#PA5-21349; RRID:AB_11153785 APC Goat anti-mouse IgG (minimal x-reactivity) Antibody Biolegend Cat#405308; RRID:AB_315011 Goat Anti-Guinea pig IgG H&L (Alexa Fluor® 488) Abcam Cat#ab150185; RRID:AB_2736871 Goat Anti-Mouse IgG, Human ads-AP SouthernBiotech Cat#1030-04; RRID:AB_2794293 Biological samples Lupus patient PBMCs Yale University N/A Chemicals, peptides, and recombinant proteins LIVE/DEADTM Fixable Aqua Dead Cell Stain Kit Invitrogen Cat#L34966 Recombinant Mouse IFN-gamma Protein with carrier R&D Systems Cat#485-MI-100 Recombinant Mouse TNF-alpha (aa 80-235) Protein with carrier R&D Systems Cat#410-MT-025 Recombinant Mouse IL-10 Protein with carrier R&D Systems Cat#417-ML-025 Recombinant Mouse IL-12 Protein with carrier R&D Systems Cat#419-ML-010 Recombinant Mouse IL-15 Protein with carrier R&D Systems Ca#447-ML-010 Recombinant Mouse IL-18/IL-1F4 Protein with carrier R&D Systems Cat#9139-IL-050 Recombinant Mouse IL-21 Protein with carrier R&D Systems Cat#594-ML-025 Universal Type I IFN Protein R&D Systems Cat#11200-1 Human IL-2 Recombinant Protein PeproTech Cat#200-02 (Continued on next page) ll OPEN ACCESSArticle Immunity 59, 1–21.e1–e15, June 9, 2026 e2 .. REAGENT or RESOURCE SOURCE IDENTIFIER Recombinant Human IL-15 Protein, CF R&D Systems Cat#BT-015-010 Recombinant Human IL-21 Protein with carrier R&D Systems Cat#8879-IL-010 FTY720 MilliporeSigma Cat344597; CAS:162359-56-0 Deoxyribonucleic acid from calf thymus MilliporeSigma Cat#D4522; CAS:91080-16-9 Reacti-Bind TM DNA Coating Solution Thermo Fisher Cat#17250 DAPI Nucleic Acid Stains Invitrogen Cat#D1306 ProLongTM Gold Antifade Mountant Invitrogen Cat#P36930 Collagenase from Clostridium histolyticum MilliporeSigma Cat#C9263; CAS: 9001-12-1 Renal Epithelial Cell Basal Medium ATCC Cat#PCS-400-030 Critical commercial assays Chromium Next GEM Single Cell Multiome ATAC + Gene Expression 10x Genomics Cat#CG000365 Chromium GEM-X Single Cell 5’ Kit 10x Genomics Cat#CG000733 EasySep Mouse CD4+ TCell Isolation Kit STEMCELL Technologies Cat#19852 EasySep Mouse CD8+ TCell Isolation Kit STEMCELL Technologies Cat#19853A EasySepTM Human CD8+ T Cell Isolation Kit STEMCELL Technologies Cat#17953 eBioscienceTM Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent Invitrogen Cat#00-5521-00 PierceTM Bradford Protein Assay Kit Thermo Scientific Cat#23200 QuantiChromTM Creatinine Assay Kit BioAssay Systems Cat#DICT-500 BD PharmingenTM PE Annexin V Apoptosis Detection Kit I BD Biosciences Cat#559763; RRID:AB_2869265 Deposited data Mouse single cell sequencing data This study Gene Expression Omnibus (GEO) accession number: GSE318514 Human single cell sequencing data Accelerating Medicines Partnership Phase II RA/SLE AMP2 Lupus Kidney Single Cell Mouse strains MRL/MpJ-Faslpr/J The Jackson Laboratory 000485; RRID:IMSR_JAX:000485 NZBWF1/J The Jackson Laboratory 100008; RRID:IMSR_JAX:100008 B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ The Jackson Laboratory 021569; RRID:IMSR_JAX:021569 B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J The Jackson Laboratory 018974; RRID:IMSR_JAX:018974 C57BL/6J The Jackson Laboratory 000664; RRID:IMSR_JAX:000664 MRL/MpJ-Faslpr/J × B6N.B6-Tg(Nr4a1EGFP/cre)820Khog This study N/A MRL/MpJ-Faslpr/J.TCRβ-/- Peng et al.53 10.1084/jem.184.3.1149 Software and algorithms FlowJo v10.8.1 TreeStar FlowJo LLC. .. RRID:SCR_008520 GraphPad Prism v9.5.1 GraphPad Software RRID:SCR_002798 ImageJ imagej.net/ij RRID:SCR_003070 CellRanger v5.0.1 10xgenomics.com/support/software/ cell-ranger RRID:SCR_023221 R version 4.2.0 r-project.org RRID:SCR_001905 chromVAR v1.18 bioconductor.org/packages/chromVAR RRID:SCR_026570 circlize v0.4.16 cran.r-project.org/web/packages/circlize RRID:SCR_002141 cisTopic v0.3.0 github.com/aertslab/cisTopic N/A clusterProfiler v4.6.2 bioconductor.org/packages/clusterProfiler RRID:SCR_016884 Clustree v0.5.0 cran.r-project.org/web/packages/ clustree/index RRID:SCR_016293 (Continued on next page) ll OPEN ACCESS Article e3 Immunity 59, 1–21.e1–e15, June 9, 2026

    Cell Isolation:

    Article Title: Organ injury in systemic autoimmunity is mediated by stem-like CD8 + T cells arising from tissue-draining lymph nodes.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PE anti-mouse IL-21R Antibody Biolegend Cat#131906; RRID:AB_1279430 BD PharmingenTM Purified NA/LE Hamster Anti-Mouse CD3e BD Biosciences Cat#553057; RRID:AB_394590 BD PharmingenTM Purified NA/LE Mouse Anti-Mouse CD28 BD Biosciences Cat#566883; RRID:AB_2869934 Ultra-LEAFTM Purified anti-mouse CD8a Antibody Biolegend Cat#100764; RRID:AB_2810324 Ultra-LEAFTM Purified Rat IgG2a, κ Isotype Ctrl Antibody Biolegend Cat#400566; RRID:AB_11148951 TotalSeqTM-C0301 anti-mouse Hashtag 1 Antibody Biolegend Cat#155861; RRID:AB_2800693 TotalSeqTM-C0302 anti-mouse Hashtag 2 Antibody Biolegend Cat#155863; RRID:AB_2800694 TotalSeqTM-C0303 anti-mouse Hashtag 3 Antibody Biolegend Cat#155865; RRID:AB_2800695 InVivoMAb rat IgG2a isotype control, antitrinitrophenol BioXCell Cat#BE0089; RRID:AB_1107769 InVivoMAb anti-mouse CD122 (IL-2Rβ) BioXCell Cat#BE0272; RRID:AB_2687795 InVivoMAb anti-mouse IL-21R BioXCell Cat#BE0258; RRID:AB_2687737 InVivoMAb anti-mouse PD-1 (CD279) BioXCell Cat#BE0273; RRID:AB_2687796 CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscienceTM Invitrogen Cat#16-0037-85; RRID:AB_468855 CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscienceTM Invitrogen Cat#16-0289-85; RRID:AB_468927 anti-Nephrin guinea pig polyclonal, serum PROGEN Cat#GP-N2; RRID:AB_2904121 Complement C3 Polyclonal Antibody Invitrogen Cat#PA5-21349; RRID:AB_11153785 APC Goat anti-mouse IgG (minimal x-reactivity) Antibody Biolegend Cat#405308; RRID:AB_315011 Goat Anti-Guinea pig IgG H&L (Alexa Fluor® 488) Abcam Cat#ab150185; RRID:AB_2736871 Goat Anti-Mouse IgG, Human ads-AP SouthernBiotech Cat#1030-04; RRID:AB_2794293 Biological samples Lupus patient PBMCs Yale University N/A Chemicals, peptides, and recombinant proteins LIVE/DEADTM Fixable Aqua Dead Cell Stain Kit Invitrogen Cat#L34966 Recombinant Mouse IFN-gamma Protein with carrier R&D Systems Cat#485-MI-100 Recombinant Mouse TNF-alpha (aa 80-235) Protein with carrier R&D Systems Cat#410-MT-025 Recombinant Mouse IL-10 Protein with carrier R&D Systems Cat#417-ML-025 Recombinant Mouse IL-12 Protein with carrier R&D Systems Cat#419-ML-010 Recombinant Mouse IL-15 Protein with carrier R&D Systems Ca#447-ML-010 Recombinant Mouse IL-18/IL-1F4 Protein with carrier R&D Systems Cat#9139-IL-050 Recombinant Mouse IL-21 Protein with carrier R&D Systems Cat#594-ML-025 Universal Type I IFN Protein R&D Systems Cat#11200-1 Human IL-2 Recombinant Protein PeproTech Cat#200-02 (Continued on next page) ll OPEN ACCESSArticle Immunity 59, 1–21.e1–e15, June 9, 2026 e2 .. REAGENT or RESOURCE SOURCE IDENTIFIER Recombinant Human IL-15 Protein, CF R&D Systems Cat#BT-015-010 Recombinant Human IL-21 Protein with carrier R&D Systems Cat#8879-IL-010 FTY720 MilliporeSigma Cat344597; CAS:162359-56-0 Deoxyribonucleic acid from calf thymus MilliporeSigma Cat#D4522; CAS:91080-16-9 Reacti-Bind TM DNA Coating Solution Thermo Fisher Cat#17250 DAPI Nucleic Acid Stains Invitrogen Cat#D1306 ProLongTM Gold Antifade Mountant Invitrogen Cat#P36930 Collagenase from Clostridium histolyticum MilliporeSigma Cat#C9263; CAS: 9001-12-1 Renal Epithelial Cell Basal Medium ATCC Cat#PCS-400-030 Critical commercial assays Chromium Next GEM Single Cell Multiome ATAC + Gene Expression 10x Genomics Cat#CG000365 Chromium GEM-X Single Cell 5’ Kit 10x Genomics Cat#CG000733 EasySep Mouse CD4+ TCell Isolation Kit STEMCELL Technologies Cat#19852 EasySep Mouse CD8+ TCell Isolation Kit STEMCELL Technologies Cat#19853A EasySepTM Human CD8+ T Cell Isolation Kit STEMCELL Technologies Cat#17953 eBioscienceTM Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent Invitrogen Cat#00-5521-00 PierceTM Bradford Protein Assay Kit Thermo Scientific Cat#23200 QuantiChromTM Creatinine Assay Kit BioAssay Systems Cat#DICT-500 BD PharmingenTM PE Annexin V Apoptosis Detection Kit I BD Biosciences Cat#559763; RRID:AB_2869265 Deposited data Mouse single cell sequencing data This study Gene Expression Omnibus (GEO) accession number: GSE318514 Human single cell sequencing data Accelerating Medicines Partnership Phase II RA/SLE AMP2 Lupus Kidney Single Cell Mouse strains MRL/MpJ-Faslpr/J The Jackson Laboratory 000485; RRID:IMSR_JAX:000485 NZBWF1/J The Jackson Laboratory 100008; RRID:IMSR_JAX:100008 B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ The Jackson Laboratory 021569; RRID:IMSR_JAX:021569 B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J The Jackson Laboratory 018974; RRID:IMSR_JAX:018974 C57BL/6J The Jackson Laboratory 000664; RRID:IMSR_JAX:000664 MRL/MpJ-Faslpr/J × B6N.B6-Tg(Nr4a1EGFP/cre)820Khog This study N/A MRL/MpJ-Faslpr/J.TCRβ-/- Peng et al.53 10.1084/jem.184.3.1149 Software and algorithms FlowJo v10.8.1 TreeStar FlowJo LLC. .. RRID:SCR_008520 GraphPad Prism v9.5.1 GraphPad Software RRID:SCR_002798 ImageJ imagej.net/ij RRID:SCR_003070 CellRanger v5.0.1 10xgenomics.com/support/software/ cell-ranger RRID:SCR_023221 R version 4.2.0 r-project.org RRID:SCR_001905 chromVAR v1.18 bioconductor.org/packages/chromVAR RRID:SCR_026570 circlize v0.4.16 cran.r-project.org/web/packages/circlize RRID:SCR_002141 cisTopic v0.3.0 github.com/aertslab/cisTopic N/A clusterProfiler v4.6.2 bioconductor.org/packages/clusterProfiler RRID:SCR_016884 Clustree v0.5.0 cran.r-project.org/web/packages/ clustree/index RRID:SCR_016293 (Continued on next page) ll OPEN ACCESS Article e3 Immunity 59, 1–21.e1–e15, June 9, 2026

    Bradford Protein Assay:

    Article Title: Organ injury in systemic autoimmunity is mediated by stem-like CD8 + T cells arising from tissue-draining lymph nodes.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PE anti-mouse IL-21R Antibody Biolegend Cat#131906; RRID:AB_1279430 BD PharmingenTM Purified NA/LE Hamster Anti-Mouse CD3e BD Biosciences Cat#553057; RRID:AB_394590 BD PharmingenTM Purified NA/LE Mouse Anti-Mouse CD28 BD Biosciences Cat#566883; RRID:AB_2869934 Ultra-LEAFTM Purified anti-mouse CD8a Antibody Biolegend Cat#100764; RRID:AB_2810324 Ultra-LEAFTM Purified Rat IgG2a, κ Isotype Ctrl Antibody Biolegend Cat#400566; RRID:AB_11148951 TotalSeqTM-C0301 anti-mouse Hashtag 1 Antibody Biolegend Cat#155861; RRID:AB_2800693 TotalSeqTM-C0302 anti-mouse Hashtag 2 Antibody Biolegend Cat#155863; RRID:AB_2800694 TotalSeqTM-C0303 anti-mouse Hashtag 3 Antibody Biolegend Cat#155865; RRID:AB_2800695 InVivoMAb rat IgG2a isotype control, antitrinitrophenol BioXCell Cat#BE0089; RRID:AB_1107769 InVivoMAb anti-mouse CD122 (IL-2Rβ) BioXCell Cat#BE0272; RRID:AB_2687795 InVivoMAb anti-mouse IL-21R BioXCell Cat#BE0258; RRID:AB_2687737 InVivoMAb anti-mouse PD-1 (CD279) BioXCell Cat#BE0273; RRID:AB_2687796 CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscienceTM Invitrogen Cat#16-0037-85; RRID:AB_468855 CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscienceTM Invitrogen Cat#16-0289-85; RRID:AB_468927 anti-Nephrin guinea pig polyclonal, serum PROGEN Cat#GP-N2; RRID:AB_2904121 Complement C3 Polyclonal Antibody Invitrogen Cat#PA5-21349; RRID:AB_11153785 APC Goat anti-mouse IgG (minimal x-reactivity) Antibody Biolegend Cat#405308; RRID:AB_315011 Goat Anti-Guinea pig IgG H&L (Alexa Fluor® 488) Abcam Cat#ab150185; RRID:AB_2736871 Goat Anti-Mouse IgG, Human ads-AP SouthernBiotech Cat#1030-04; RRID:AB_2794293 Biological samples Lupus patient PBMCs Yale University N/A Chemicals, peptides, and recombinant proteins LIVE/DEADTM Fixable Aqua Dead Cell Stain Kit Invitrogen Cat#L34966 Recombinant Mouse IFN-gamma Protein with carrier R&D Systems Cat#485-MI-100 Recombinant Mouse TNF-alpha (aa 80-235) Protein with carrier R&D Systems Cat#410-MT-025 Recombinant Mouse IL-10 Protein with carrier R&D Systems Cat#417-ML-025 Recombinant Mouse IL-12 Protein with carrier R&D Systems Cat#419-ML-010 Recombinant Mouse IL-15 Protein with carrier R&D Systems Ca#447-ML-010 Recombinant Mouse IL-18/IL-1F4 Protein with carrier R&D Systems Cat#9139-IL-050 Recombinant Mouse IL-21 Protein with carrier R&D Systems Cat#594-ML-025 Universal Type I IFN Protein R&D Systems Cat#11200-1 Human IL-2 Recombinant Protein PeproTech Cat#200-02 (Continued on next page) ll OPEN ACCESSArticle Immunity 59, 1–21.e1–e15, June 9, 2026 e2 .. REAGENT or RESOURCE SOURCE IDENTIFIER Recombinant Human IL-15 Protein, CF R&D Systems Cat#BT-015-010 Recombinant Human IL-21 Protein with carrier R&D Systems Cat#8879-IL-010 FTY720 MilliporeSigma Cat344597; CAS:162359-56-0 Deoxyribonucleic acid from calf thymus MilliporeSigma Cat#D4522; CAS:91080-16-9 Reacti-Bind TM DNA Coating Solution Thermo Fisher Cat#17250 DAPI Nucleic Acid Stains Invitrogen Cat#D1306 ProLongTM Gold Antifade Mountant Invitrogen Cat#P36930 Collagenase from Clostridium histolyticum MilliporeSigma Cat#C9263; CAS: 9001-12-1 Renal Epithelial Cell Basal Medium ATCC Cat#PCS-400-030 Critical commercial assays Chromium Next GEM Single Cell Multiome ATAC + Gene Expression 10x Genomics Cat#CG000365 Chromium GEM-X Single Cell 5’ Kit 10x Genomics Cat#CG000733 EasySep Mouse CD4+ TCell Isolation Kit STEMCELL Technologies Cat#19852 EasySep Mouse CD8+ TCell Isolation Kit STEMCELL Technologies Cat#19853A EasySepTM Human CD8+ T Cell Isolation Kit STEMCELL Technologies Cat#17953 eBioscienceTM Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent Invitrogen Cat#00-5521-00 PierceTM Bradford Protein Assay Kit Thermo Scientific Cat#23200 QuantiChromTM Creatinine Assay Kit BioAssay Systems Cat#DICT-500 BD PharmingenTM PE Annexin V Apoptosis Detection Kit I BD Biosciences Cat#559763; RRID:AB_2869265 Deposited data Mouse single cell sequencing data This study Gene Expression Omnibus (GEO) accession number: GSE318514 Human single cell sequencing data Accelerating Medicines Partnership Phase II RA/SLE AMP2 Lupus Kidney Single Cell Mouse strains MRL/MpJ-Faslpr/J The Jackson Laboratory 000485; RRID:IMSR_JAX:000485 NZBWF1/J The Jackson Laboratory 100008; RRID:IMSR_JAX:100008 B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ The Jackson Laboratory 021569; RRID:IMSR_JAX:021569 B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J The Jackson Laboratory 018974; RRID:IMSR_JAX:018974 C57BL/6J The Jackson Laboratory 000664; RRID:IMSR_JAX:000664 MRL/MpJ-Faslpr/J × B6N.B6-Tg(Nr4a1EGFP/cre)820Khog This study N/A MRL/MpJ-Faslpr/J.TCRβ-/- Peng et al.53 10.1084/jem.184.3.1149 Software and algorithms FlowJo v10.8.1 TreeStar FlowJo LLC. .. RRID:SCR_008520 GraphPad Prism v9.5.1 GraphPad Software RRID:SCR_002798 ImageJ imagej.net/ij RRID:SCR_003070 CellRanger v5.0.1 10xgenomics.com/support/software/ cell-ranger RRID:SCR_023221 R version 4.2.0 r-project.org RRID:SCR_001905 chromVAR v1.18 bioconductor.org/packages/chromVAR RRID:SCR_026570 circlize v0.4.16 cran.r-project.org/web/packages/circlize RRID:SCR_002141 cisTopic v0.3.0 github.com/aertslab/cisTopic N/A clusterProfiler v4.6.2 bioconductor.org/packages/clusterProfiler RRID:SCR_016884 Clustree v0.5.0 cran.r-project.org/web/packages/ clustree/index RRID:SCR_016293 (Continued on next page) ll OPEN ACCESS Article e3 Immunity 59, 1–21.e1–e15, June 9, 2026

    Sequencing:

    Article Title: Organ injury in systemic autoimmunity is mediated by stem-like CD8 + T cells arising from tissue-draining lymph nodes.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PE anti-mouse IL-21R Antibody Biolegend Cat#131906; RRID:AB_1279430 BD PharmingenTM Purified NA/LE Hamster Anti-Mouse CD3e BD Biosciences Cat#553057; RRID:AB_394590 BD PharmingenTM Purified NA/LE Mouse Anti-Mouse CD28 BD Biosciences Cat#566883; RRID:AB_2869934 Ultra-LEAFTM Purified anti-mouse CD8a Antibody Biolegend Cat#100764; RRID:AB_2810324 Ultra-LEAFTM Purified Rat IgG2a, κ Isotype Ctrl Antibody Biolegend Cat#400566; RRID:AB_11148951 TotalSeqTM-C0301 anti-mouse Hashtag 1 Antibody Biolegend Cat#155861; RRID:AB_2800693 TotalSeqTM-C0302 anti-mouse Hashtag 2 Antibody Biolegend Cat#155863; RRID:AB_2800694 TotalSeqTM-C0303 anti-mouse Hashtag 3 Antibody Biolegend Cat#155865; RRID:AB_2800695 InVivoMAb rat IgG2a isotype control, antitrinitrophenol BioXCell Cat#BE0089; RRID:AB_1107769 InVivoMAb anti-mouse CD122 (IL-2Rβ) BioXCell Cat#BE0272; RRID:AB_2687795 InVivoMAb anti-mouse IL-21R BioXCell Cat#BE0258; RRID:AB_2687737 InVivoMAb anti-mouse PD-1 (CD279) BioXCell Cat#BE0273; RRID:AB_2687796 CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscienceTM Invitrogen Cat#16-0037-85; RRID:AB_468855 CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscienceTM Invitrogen Cat#16-0289-85; RRID:AB_468927 anti-Nephrin guinea pig polyclonal, serum PROGEN Cat#GP-N2; RRID:AB_2904121 Complement C3 Polyclonal Antibody Invitrogen Cat#PA5-21349; RRID:AB_11153785 APC Goat anti-mouse IgG (minimal x-reactivity) Antibody Biolegend Cat#405308; RRID:AB_315011 Goat Anti-Guinea pig IgG H&L (Alexa Fluor® 488) Abcam Cat#ab150185; RRID:AB_2736871 Goat Anti-Mouse IgG, Human ads-AP SouthernBiotech Cat#1030-04; RRID:AB_2794293 Biological samples Lupus patient PBMCs Yale University N/A Chemicals, peptides, and recombinant proteins LIVE/DEADTM Fixable Aqua Dead Cell Stain Kit Invitrogen Cat#L34966 Recombinant Mouse IFN-gamma Protein with carrier R&D Systems Cat#485-MI-100 Recombinant Mouse TNF-alpha (aa 80-235) Protein with carrier R&D Systems Cat#410-MT-025 Recombinant Mouse IL-10 Protein with carrier R&D Systems Cat#417-ML-025 Recombinant Mouse IL-12 Protein with carrier R&D Systems Cat#419-ML-010 Recombinant Mouse IL-15 Protein with carrier R&D Systems Ca#447-ML-010 Recombinant Mouse IL-18/IL-1F4 Protein with carrier R&D Systems Cat#9139-IL-050 Recombinant Mouse IL-21 Protein with carrier R&D Systems Cat#594-ML-025 Universal Type I IFN Protein R&D Systems Cat#11200-1 Human IL-2 Recombinant Protein PeproTech Cat#200-02 (Continued on next page) ll OPEN ACCESSArticle Immunity 59, 1–21.e1–e15, June 9, 2026 e2 .. REAGENT or RESOURCE SOURCE IDENTIFIER Recombinant Human IL-15 Protein, CF R&D Systems Cat#BT-015-010 Recombinant Human IL-21 Protein with carrier R&D Systems Cat#8879-IL-010 FTY720 MilliporeSigma Cat344597; CAS:162359-56-0 Deoxyribonucleic acid from calf thymus MilliporeSigma Cat#D4522; CAS:91080-16-9 Reacti-Bind TM DNA Coating Solution Thermo Fisher Cat#17250 DAPI Nucleic Acid Stains Invitrogen Cat#D1306 ProLongTM Gold Antifade Mountant Invitrogen Cat#P36930 Collagenase from Clostridium histolyticum MilliporeSigma Cat#C9263; CAS: 9001-12-1 Renal Epithelial Cell Basal Medium ATCC Cat#PCS-400-030 Critical commercial assays Chromium Next GEM Single Cell Multiome ATAC + Gene Expression 10x Genomics Cat#CG000365 Chromium GEM-X Single Cell 5’ Kit 10x Genomics Cat#CG000733 EasySep Mouse CD4+ TCell Isolation Kit STEMCELL Technologies Cat#19852 EasySep Mouse CD8+ TCell Isolation Kit STEMCELL Technologies Cat#19853A EasySepTM Human CD8+ T Cell Isolation Kit STEMCELL Technologies Cat#17953 eBioscienceTM Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent Invitrogen Cat#00-5521-00 PierceTM Bradford Protein Assay Kit Thermo Scientific Cat#23200 QuantiChromTM Creatinine Assay Kit BioAssay Systems Cat#DICT-500 BD PharmingenTM PE Annexin V Apoptosis Detection Kit I BD Biosciences Cat#559763; RRID:AB_2869265 Deposited data Mouse single cell sequencing data This study Gene Expression Omnibus (GEO) accession number: GSE318514 Human single cell sequencing data Accelerating Medicines Partnership Phase II RA/SLE AMP2 Lupus Kidney Single Cell Mouse strains MRL/MpJ-Faslpr/J The Jackson Laboratory 000485; RRID:IMSR_JAX:000485 NZBWF1/J The Jackson Laboratory 100008; RRID:IMSR_JAX:100008 B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ The Jackson Laboratory 021569; RRID:IMSR_JAX:021569 B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J The Jackson Laboratory 018974; RRID:IMSR_JAX:018974 C57BL/6J The Jackson Laboratory 000664; RRID:IMSR_JAX:000664 MRL/MpJ-Faslpr/J × B6N.B6-Tg(Nr4a1EGFP/cre)820Khog This study N/A MRL/MpJ-Faslpr/J.TCRβ-/- Peng et al.53 10.1084/jem.184.3.1149 Software and algorithms FlowJo v10.8.1 TreeStar FlowJo LLC. .. RRID:SCR_008520 GraphPad Prism v9.5.1 GraphPad Software RRID:SCR_002798 ImageJ imagej.net/ij RRID:SCR_003070 CellRanger v5.0.1 10xgenomics.com/support/software/ cell-ranger RRID:SCR_023221 R version 4.2.0 r-project.org RRID:SCR_001905 chromVAR v1.18 bioconductor.org/packages/chromVAR RRID:SCR_026570 circlize v0.4.16 cran.r-project.org/web/packages/circlize RRID:SCR_002141 cisTopic v0.3.0 github.com/aertslab/cisTopic N/A clusterProfiler v4.6.2 bioconductor.org/packages/clusterProfiler RRID:SCR_016884 Clustree v0.5.0 cran.r-project.org/web/packages/ clustree/index RRID:SCR_016293 (Continued on next page) ll OPEN ACCESS Article e3 Immunity 59, 1–21.e1–e15, June 9, 2026

    Software:

    Article Title: Organ injury in systemic autoimmunity is mediated by stem-like CD8 + T cells arising from tissue-draining lymph nodes.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER PE anti-mouse IL-21R Antibody Biolegend Cat#131906; RRID:AB_1279430 BD PharmingenTM Purified NA/LE Hamster Anti-Mouse CD3e BD Biosciences Cat#553057; RRID:AB_394590 BD PharmingenTM Purified NA/LE Mouse Anti-Mouse CD28 BD Biosciences Cat#566883; RRID:AB_2869934 Ultra-LEAFTM Purified anti-mouse CD8a Antibody Biolegend Cat#100764; RRID:AB_2810324 Ultra-LEAFTM Purified Rat IgG2a, κ Isotype Ctrl Antibody Biolegend Cat#400566; RRID:AB_11148951 TotalSeqTM-C0301 anti-mouse Hashtag 1 Antibody Biolegend Cat#155861; RRID:AB_2800693 TotalSeqTM-C0302 anti-mouse Hashtag 2 Antibody Biolegend Cat#155863; RRID:AB_2800694 TotalSeqTM-C0303 anti-mouse Hashtag 3 Antibody Biolegend Cat#155865; RRID:AB_2800695 InVivoMAb rat IgG2a isotype control, antitrinitrophenol BioXCell Cat#BE0089; RRID:AB_1107769 InVivoMAb anti-mouse CD122 (IL-2Rβ) BioXCell Cat#BE0272; RRID:AB_2687795 InVivoMAb anti-mouse IL-21R BioXCell Cat#BE0258; RRID:AB_2687737 InVivoMAb anti-mouse PD-1 (CD279) BioXCell Cat#BE0273; RRID:AB_2687796 CD3 Monoclonal Antibody (OKT3), Functional Grade, eBioscienceTM Invitrogen Cat#16-0037-85; RRID:AB_468855 CD28 Monoclonal Antibody (CD28.2), Functional Grade, eBioscienceTM Invitrogen Cat#16-0289-85; RRID:AB_468927 anti-Nephrin guinea pig polyclonal, serum PROGEN Cat#GP-N2; RRID:AB_2904121 Complement C3 Polyclonal Antibody Invitrogen Cat#PA5-21349; RRID:AB_11153785 APC Goat anti-mouse IgG (minimal x-reactivity) Antibody Biolegend Cat#405308; RRID:AB_315011 Goat Anti-Guinea pig IgG H&L (Alexa Fluor® 488) Abcam Cat#ab150185; RRID:AB_2736871 Goat Anti-Mouse IgG, Human ads-AP SouthernBiotech Cat#1030-04; RRID:AB_2794293 Biological samples Lupus patient PBMCs Yale University N/A Chemicals, peptides, and recombinant proteins LIVE/DEADTM Fixable Aqua Dead Cell Stain Kit Invitrogen Cat#L34966 Recombinant Mouse IFN-gamma Protein with carrier R&D Systems Cat#485-MI-100 Recombinant Mouse TNF-alpha (aa 80-235) Protein with carrier R&D Systems Cat#410-MT-025 Recombinant Mouse IL-10 Protein with carrier R&D Systems Cat#417-ML-025 Recombinant Mouse IL-12 Protein with carrier R&D Systems Cat#419-ML-010 Recombinant Mouse IL-15 Protein with carrier R&D Systems Ca#447-ML-010 Recombinant Mouse IL-18/IL-1F4 Protein with carrier R&D Systems Cat#9139-IL-050 Recombinant Mouse IL-21 Protein with carrier R&D Systems Cat#594-ML-025 Universal Type I IFN Protein R&D Systems Cat#11200-1 Human IL-2 Recombinant Protein PeproTech Cat#200-02 (Continued on next page) ll OPEN ACCESSArticle Immunity 59, 1–21.e1–e15, June 9, 2026 e2 .. REAGENT or RESOURCE SOURCE IDENTIFIER Recombinant Human IL-15 Protein, CF R&D Systems Cat#BT-015-010 Recombinant Human IL-21 Protein with carrier R&D Systems Cat#8879-IL-010 FTY720 MilliporeSigma Cat344597; CAS:162359-56-0 Deoxyribonucleic acid from calf thymus MilliporeSigma Cat#D4522; CAS:91080-16-9 Reacti-Bind TM DNA Coating Solution Thermo Fisher Cat#17250 DAPI Nucleic Acid Stains Invitrogen Cat#D1306 ProLongTM Gold Antifade Mountant Invitrogen Cat#P36930 Collagenase from Clostridium histolyticum MilliporeSigma Cat#C9263; CAS: 9001-12-1 Renal Epithelial Cell Basal Medium ATCC Cat#PCS-400-030 Critical commercial assays Chromium Next GEM Single Cell Multiome ATAC + Gene Expression 10x Genomics Cat#CG000365 Chromium GEM-X Single Cell 5’ Kit 10x Genomics Cat#CG000733 EasySep Mouse CD4+ TCell Isolation Kit STEMCELL Technologies Cat#19852 EasySep Mouse CD8+ TCell Isolation Kit STEMCELL Technologies Cat#19853A EasySepTM Human CD8+ T Cell Isolation Kit STEMCELL Technologies Cat#17953 eBioscienceTM Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent Invitrogen Cat#00-5521-00 PierceTM Bradford Protein Assay Kit Thermo Scientific Cat#23200 QuantiChromTM Creatinine Assay Kit BioAssay Systems Cat#DICT-500 BD PharmingenTM PE Annexin V Apoptosis Detection Kit I BD Biosciences Cat#559763; RRID:AB_2869265 Deposited data Mouse single cell sequencing data This study Gene Expression Omnibus (GEO) accession number: GSE318514 Human single cell sequencing data Accelerating Medicines Partnership Phase II RA/SLE AMP2 Lupus Kidney Single Cell Mouse strains MRL/MpJ-Faslpr/J The Jackson Laboratory 000485; RRID:IMSR_JAX:000485 NZBWF1/J The Jackson Laboratory 100008; RRID:IMSR_JAX:100008 B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ The Jackson Laboratory 021569; RRID:IMSR_JAX:021569 B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J The Jackson Laboratory 018974; RRID:IMSR_JAX:018974 C57BL/6J The Jackson Laboratory 000664; RRID:IMSR_JAX:000664 MRL/MpJ-Faslpr/J × B6N.B6-Tg(Nr4a1EGFP/cre)820Khog This study N/A MRL/MpJ-Faslpr/J.TCRβ-/- Peng et al.53 10.1084/jem.184.3.1149 Software and algorithms FlowJo v10.8.1 TreeStar FlowJo LLC. .. RRID:SCR_008520 GraphPad Prism v9.5.1 GraphPad Software RRID:SCR_002798 ImageJ imagej.net/ij RRID:SCR_003070 CellRanger v5.0.1 10xgenomics.com/support/software/ cell-ranger RRID:SCR_023221 R version 4.2.0 r-project.org RRID:SCR_001905 chromVAR v1.18 bioconductor.org/packages/chromVAR RRID:SCR_026570 circlize v0.4.16 cran.r-project.org/web/packages/circlize RRID:SCR_002141 cisTopic v0.3.0 github.com/aertslab/cisTopic N/A clusterProfiler v4.6.2 bioconductor.org/packages/clusterProfiler RRID:SCR_016884 Clustree v0.5.0 cran.r-project.org/web/packages/ clustree/index RRID:SCR_016293 (Continued on next page) ll OPEN ACCESS Article e3 Immunity 59, 1–21.e1–e15, June 9, 2026



    Similar Products

    resource source identifier recombinant human il 15 protein  (R&D Systems)
    95
    R&D Systems resource source identifier recombinant human il 15 protein
    Resource Source Identifier Recombinant Human Il 15 Protein, supplied by R&D Systems, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/resource+source+identifier+recombinant+human+il+15+protein/Recombinant+Human+IL-15+Protein/pm42013863-236-2-10
    Average 95 stars, based on 1 article reviews
    resource source identifier recombinant human il 15 protein - by Bioz Stars, 2026-09
    95/100 stars
    		  Buy from Supplier

    Image Search Results